Polycystins: Mechanosensors with Diagnostic and Prognostic Potential in Cancer

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• 作者：Antonios N. Gargalionis¹ ; Kostas A. Papavassiliou¹ ; Efthimia K. Basdra¹ ; Athanasios G. Papavassiliou¹ ; ^{papavas@med.uoa.gr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：polycystins ; mechanosensor ; signal transduction ; biomarker ; cancer ; metastasis
• 刊名：Trends in Molecular Medicine
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：22
• 期：1
• 页码：7-9
• 全文大小：594 K

文摘

Polycystins are key regulators of cell-to-cell and cell-to-extracellular matrix (ECM) physical interactions that have been recently implicated in oncogenic mechanisms. Polycystins may be emerging as potential diagnostic and prognostic markers in specific types of malignancy, offering a promising research area for the development of novel biomarkers in solid tumors.