Polycystins and intercellular mechanotransduction: A precise dosage of polycystin 2 is necessary for alpha-actinin reinforcement of junctions upon mechanical stimulation
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- 作者：Laxsoomee Bhoonderowaa ; b ; Fatima Hameurlainea ; b ; Atousa Arbabiana ; b ; Fahima Faqira ; b ; Franç ; ois Amblarda ; b ; Sylvie Coscoya ; b ; Sylvie.Coscoy@curie.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Polycystin ; Alpha-actinin ; Cytoskeleton ; Mechanotransduction ; Cell junction ; Epithelial cells ; Ion channel
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：348
- 期：1
- 页码：23-35
- 全文大小：3049 K
文摘
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Mechanical stimulation of junctions was performed in cells modified for polycystin 2.intercellular
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Alpha-actinin recruitment upon stimulation, and multicellular behavior, were altered.
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This strongly suggests that polycystin 2 is involved in junctional mechanotransduction.
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Polycystin localization at intercellular contacts may play a role in cyst formation.