The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs
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- 作者：Peter S. Shen1 ; 7 ; Xiaoyong Yang1 ; 7 ; Paul G. DeCaen2 ; 4 ; 5 ; 6 ; Xiaowen Liu4 ; 5 ; 6 ; David Bulkley3 ; David E. Clapham4 ; 5 ; 6 ; dclapham@enders.tch.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Erhu Cao1 ; 8 ; erhu.cao@biochem.utah.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：polycystic kidney disease ; ADPKD ; PKD2 ; TRPP2 ; TRP channel ; single particle electron cryo-microscopy ; cryo-EM ; ion channel ; polycystin
- 刊名：Cell
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：167
- 期：3
- 页码：763-773.e11
- 全文大小：9159 K
文摘
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3.0 Å resolution cryo-EM structure of PKD2 in lipid nanodiscs
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Two gates regulate ion permeation
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The extracellular polycystin domain contributes to channel assembly
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The structure reveals the molecular basis of the majority of pathogenic mutations