Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis

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• 作者：Maria A. Katsianou^a ; Christos Adamopoulos^a ; Heleni Vastardis^b ; Efthimia K. Basdra^a ; ^{ebasdra@med.uoa.gr} ; ^{tegk.84@gmail.com}
• 关键词：Sutures ; Craniosynostosis ; Molecular signaling ; Polycystins ; Mechanical stimuli ; Craniosynostosis therapies
• 刊名：BBA Clinical
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：6
• 期：Complete
• 页码：165-176
• 全文大小：1021 K
• 卷排序：6

文摘

Cranial sutures operate as bone growth sites. Premature fusion of one or more cranial sutures can trigger craniosynostosis. Several genes are involved in the pathogenesis of craniosynostosis syndromes. An array of molecular signaling events determine suture fate. Herein, the signal transduction pathways implicated in suture pathobiology are discussed.