Compositional and functional diversity of canonical PRC1 complexes in mammals

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• 作者：Katelyn E. Connelly^a ; Emily C. Dykhuizen^a ; ^b ; ^{edykhui@purdue.edu}
• 关键词：bps ; base pairs ; PcG ; Polycomb Group ; PRC1 ; Polycomb Repressive Complex 1 ; PRC2 ; Polycomb Repressive Complex 2 ; Pc ; Polycomb ; Ph ; Polyhomeotic ; Psc ; Posterior sex combs ; Sce ; Sex combs extra ; H3K27me3 ; histone H3 lysine 27 trimethylation ; SAM ; sterile alpha motif ; PCGF ; Polycomb Group Finger ; PHC ; human Polyhomeotic ; CBX ; chromobox homolog ; PREs ; Polycomb Response Elements ; MLL ; mixed lineage leukemia ; SWI/SNF ; Switch/sucrose non-fermentable ; PRE ; Polycomb Response Element ; ESC ; embryonic stem c
• 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1860
• 期：2
• 页码：233-245
• 全文大小：1049 K
• 卷排序：1860

文摘

PRC1 complexes in mammals are highly heterogeneous. Cell-type specific PRC1 complexes are important during development. PRC1 subunits contribute unique biochemical properties to the overall function. PRC1 can be targeted across the genome through a variety of different mechanisms.