Increased white matter neuron density in a rat model of maternal immune activation — Implications for schizophrenia
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- 作者：Ryan J. Duchatela ; c ; d ; e ; ryan.duchatel@uon.edu.au" class="auth_mail" title="E-mail the corresponding author ; Phillip Joblinga ; c ; d ; Phillip.Jobling@newcastle.edu.au" class="auth_mail" title="E-mail the corresponding author ; Brett A. Grahama ; c ; d ; Brett.Graham@newcastle.edu.au" class="auth_mail" title="E-mail the corresponding author ; Lauren R. Harmsb ; e ; Lauren.Harms@newcastle.edu.au" class="auth_mail" title="E-mail the corresponding author ; Patricia T. Michieb ; e ; Pat.Michie@newcastle.edu.au" class="auth_mail" title="E-mail the corresponding author ; Deborah M. Hodgsonb ; e ; Deborah.Hodgson@newcastle.edu.au" class="auth_mail" title="E-mail the corresponding author ; Paul A. Tooneya ; c ; d ; e ; paul.tooney@newcastle.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：GD ; gestational day ; GAD ; glutamic acid decarboxylase ; IL ; interleukin ; IWMN ; interstitial white matter neuron ; MIA ; maternal immune activation ; PolyI ; C ; polyinosinic ; polycytidylic acid ; NeuN ; neuronal nuclei protein ; SST ; somatostatin
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 February 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：118-126
- 全文大小：1261 K
文摘
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Affect of maternal immune activation on white matter neuron pathology was studied.
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Neurons were observed in the white matter of the corpus callosum of the rat brain.
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Some of these white matter neurons contain somatostatin.
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Maternal immune activation increased somatostatin+ white matter neuron density.
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This white matter neuron pathology is similar to that observed in schizophrenia.