IL-10 plays a central regulatory role in the cytokines induced by hepatitis C virus core protein and polyinosinic acid:polycytodylic acid
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文摘

IL-10 leads to the suppression of TNF-α and IL-1β through inhibiting NFκB.

IL-10 reduces the type I IFN level via downregulating STAT1 and IRF1.

TNF-α, IL-1β, and type I IFN increase IL-10 production.

IL-10 counters hepatic inflammation and HCV clearance.

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