Two new triterpenoids and a new naphthoquinone derivative isolated from a hard coral-derived fungus Scopulariopsis sp.

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• 作者：Mohamed S. Elnaggar^a ; ^b ; Sherif S. Ebada^b ; Mohamed L. Ashour^b ; Weaam Ebrahim^a ; ^c ; Abdelnasser Singab^b ; Wenhan Lin^d ; Zhen Liu^a ; ^{zhenfeizi0@sina.com} ; Peter Proksch^a ; ^{proksch@uni-duesseldorf.de}
• 关键词：Scopulariopsis sp. ; Coral-derived fungi ; OSMAC ; Triterpenoids
• 刊名：Fitoterapia
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：116
• 期：Complete
• 页码：126-130
• 全文大小：429 K
• 卷排序：116

文摘

Scopulariopsis sp. isolated from the Red Sea hard coral Stylophora sp. yielded two new triterpenoids (1–2) and a new naphthoquinone derivative (8) when cultured on white beans. In addition, fourteen known compounds including three triterpene analogues (3–5), two sesquiterpenoids (6–7), two polyketides (9–10) and seven nitrogenous compounds (11–17) were isolated. All structures were determined through extensive analysis of the NMR and MS data as well as by comparison with literature data. All isolated compounds were evaluated for their cytotoxic, antibacterial and antitubercular activities. However, none of them showed significant activity.