Polyadenylation of RNA transcribed from mammalian SINEs by RNA polymerase III: Complex requirements for nucleotide sequences
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- 作者：Olga R. Borodulina ; Julia S. Golubchikova ; Ilia G. Ustyantsev ; Dmitri A. Kramerov ; kramerov@eimb.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：CFIm ; Cleavage factor Im ; CPSF ; Cleavage and polyadenylation specificity factor ; CstF ; Cleavage stimulation factor ; CTD ; C-terminal domain ; LINE ; Long Interspersed Element ; PAP ; Polyadenosine polymerase ; PAS ; Polyadenylation signal ; pol II ; RNA polymerase II ; pol III ; RNA polymerase III ; PTB ; Polypyrimidine tract-binding protein ; SINE ; Short Interspersed Element ; TRAMP complex ; Trf4/Air2/Mtr4p Polyadenylation complex ; USE ; Upstream elements
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1859
- 期：2
- 页码：355-365
- 全文大小：1948 K
文摘
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RNA transcribed by RNA polymerase III from a number of mammalian SINEs can be polyadenylated in the cell.
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SINEs of this type contain polyadenylation signals (AATAAA) and a transcription terminator in their 3′ end region.
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Sequences located downstream of the promoter box B and upstream of the SINE tail contribute to this type of polyadenylation.
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In many SINEs, the polypyrimidine motif upstream of the AATAAA signals is involved in polyadenylation.