Molecularly imprinted polymer-based piezoelectric sensor for enantio-selective analysis of malic acid isomers

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• 作者：Bhim Bali Prasad ; ^{prof.bbpd@yahoo.com}Author Vitae ; Indu PandeyAuthor Vitae
• 关键词：d- and l-malic acid ; Molecular imprinted polymer ; Quartz crystal microbalance ; Enantio-selective sensor
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：181
• 期：Complete
• 页码：596-604
• 全文大小：1067 K

文摘

A quartz crystal microbalance sensor, having enantio-selective ability to analyze malic acid enantiomers with high sensitivity, was fabricated using a biomimetic ultra-thin film of molecularly imprinted polymer. Such material could be termed as ¡®glyco-molecularly imprinted polymer¡¯ since it was synthesized using sugar moiety, adopting non-covalent self-assembly process and subsequent photo-polymerization. The piezoelectric sensor modification via ¡°surface-grafting from¡± was found to be superior to response better than the physical entrapment of imprinted particles. The glyco-imprinted polymer sensor demonstrated exclusive specificity for l-malic acid, concomitantly present with d-malic acid and respective analogs. The rational design of malic acid/glyco-monomer complex, with composition 1:2, was predicted on the basis of theoretical modeling. The detection limit of l-malic acid was realized as 0.18-0.21 ng mL^?1 (S/N = 3, confidence level 95 % ) for l-malic acid and the linearity was observed within its concentration range 20-210 ng mL^?1, at pH 7.0, in aqueous and real samples. The proposed sensor demonstrated a fast, reliable, enantio-selective and quantitative response to malic acid isomers, in real samples.