- 作者：Rong Jiang ; rong.jiang@duke.edu ; Beverly H. Brummett ; Michael A. Babyak ; Ilene C. Siegler ; Redford B. Williams
- 关键词：BDNF Val66Met ; Depression ; Chronic stress ; Rs6265 ; CES-D
- 刊名：Journal of Psychiatric Research
- 出版年：2013
- 出版时间：February, 2013
- 年：2013
- 卷：47
- 期：2
- 页码：233-239
- 全文大小：227 K
Background
BDNF Val66Met by chronic stress interaction has been studied using childhood stress as a moderator, but has not been widely studied using chronic stress in adulthood.Methods
Two independent samples were used: Duke-CG (238 Caucasians) and MESA (5524 Caucasians, African Americans and Hispanics). Chronic stress in Duke-CG was operationalized as having primary caregiving responsibility for a spouse or relative with diagnosed Alzheimer's disease or other major dementia; chronic stress in MESA was defined using chronic burden score constructed from self-reported problems of health (self and someone close), job, finance and relationships. CES-D scale was the measure of depression in both samples. The BDNF Val66Met by adulthood chronic stress interaction predicting CES-D was examined using linear regression, adjusted for covariates.
Results
The main effect of BDNF Val66Met genotype on CES-D scores was non-significant (ps?>?0.607) but the adulthood chronic stress indicator was significant (ps?<?0.001) in both samples. The BDNF Val66Met genotype by adulthood chronic stress interaction was also significant (ps?<?0.039) in both samples. The impact of chronic stress in adulthood on CES-D scores was significantly larger in Val/Val genotype individuals than Met carriers.
Conclusion
We found in two independent samples that depression levels increased significantly more as a function of adulthood chronic stress Val/Val genotype carriers than Met carriers. Individuals with the Val/Val genotype and chronic stress exposure could be targeted for interventions designed to reduce risk of depression if this finding is confirmed in future studies.