Polyols (Glycerol and Ethylene glycol) mediated amorphous aggregate inhibition and secondary structure restoration of metalloproteinase-conalbumin (ovotransferrin)

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• 作者：Mohsin Vahid Khan^a ; Mohd Ishtikhar^a ; Gulam Rabbani^a ; Masihuz Zaman^a ; Ali Saber Abdelhameed^b ; Rizwan Hasan Khan^a ; ^{rizwanhkhan@hotmail.com} ; ^{rizwanhkhan1@yahoo.com} ; ^{rizwanhkhan1@Gmail.com}
• 关键词：Amorphous aggregates ; Conalbumin ; Congo red ; Dynamic light scattering ; Electron microscopy
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：part_PA
• 页码：290-300
• 全文大小：2015 K
• 卷排序：94

文摘

Conalbumin aggregates at 65 °C and denaturation occur at above this temperature. The nature of aggregates was identified as amorphous. The polyols inhibits the aggregation of conalbumin via protecting the secondary structure. Glycerol is found to be more protective than ethylene glycol.