High levels of MCPyV DNA were found in the normal skin of patients with MCC.
The levels were significantly higher than in healthy skins of a control cohort.
The MCPyV genotypes differed between isolates from MCC tumors and from normal skin.
MCC can occur with a background of high MCPyV load in the skin.
A patient with MCC carrying a very high load of MCPyV in normal skin is described.