Polyoxygenated cyclohexene derivatives isolated from Dasymaschalon sootepense and their biological activities

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• 作者：Sakchai Hongthong^a ; Chutima Kuhakarn^a ; ^{chutima.kon@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author} ; Thaworn Jaipetch^b ; Samran Prabpai^a ; Palangpon Kongsaeree^a ; Pawinee Piyachaturawat^c ; Surawat Jariyawat^c ; Kanoknetr Suksen^c ; Jitra Limthongkul^d ; Ampai Panthong^e ; Narong Nuntasaen^f ; Vichai Reutrakul^a
• 关键词：Dasymaschalon sootepense ; Cyclohexene oxides ; Chlorohydrins ; Cytotoxicity ; Anti-HIV-1 RT ; Anti-inflammatory
• 刊名：Fitoterapia
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：106
• 期：Complete
• 页码：158-166
• 全文大小：735 K

文摘

Six new naturally occurring polyoxygenated cyclohexene derivatives together with eight related known derivatives, two known alkaloids, and two known flavonoid derivatives were isolated from bioassay-guided fractionation of the ethyl acetate extract of the leaves and twigs of Dasymaschalon sootepense. The structure elucidation and determination of absolute configurations were established by various spectroscopic methods, X-ray diffraction techniques as well as comparison with the literature data. Several isolated compounds were evaluated for their cytotoxic, anti-HIV-1 RT and anti-inflammatory activities.