Study on quality control of sulfated polysaccharide drug, propylene glycol alginate sodium sulfate (PSS)
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- 作者：Yi-Ting Xuea ; Li Rena ; Shuang Lib ; Lin-lin Wanga ; Xiao-Xi Hea ; b ; Xia Zhaoa ; b ; Guang-li Yua ; b ; Hua-Shi Guana ; b ; Chun-Xia Lia ; b ; lchunxia@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; lichunxiaouc@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sulfated polysaccharide ; Anaphylaxis ; Anticoagulant activity ; Quality control
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：25 June 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：330-337
- 全文大小：1240 K
文摘
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The biological and chemical methods were combined to control quality of PSS.
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Purity, M/G, molecular weight and sulfate content were important to PSS quality.
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PSS fractions with higher Mw and lower M/G ratio had adverse drug reactions.
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High purity, M/G above 1.5, Mw of ∼9 kD, DS of 9.0–13.0% can ensure safety of PSS.