Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells
详细信息 查看全文
- 作者：Gibok Leea ; Taek-In Oha ; Ki Bum Uma ; Hyeshin Yoona ; Jaekyoung Sonb ; Byeong Mo Kimc ; Hong-Il Kima ; Hackyoung Kima ; Young Jun Kima ; Chang-Soo Leea ; Ji-Hong Lima ; jhlim@kku.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：USP7 inhibitor ; ER stress ; ROS ; Apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 January 2016
- 年：2016
- 卷：470
- 期：1
- 页码：181-186
- 全文大小：1677 K
文摘
- •
USP7 inhibitors induce ER stress via accumulation of polyubiquitinated proteins.
- •
ER stress caused by USP7 inhibitors leads to oxidative stress.
- •
Blocking of oxidative or ER stress attenuates USP7 inhibitor-mediated apoptosis.
- •
Oxidative/ER stress, not the p53 pathway, is critical for USP7 inhibitor-induced apoptosis.