FANK1 is a novel binding partner of proapoptotic RYBP.
The FNIII domain of FANK1 binds to the Serine/Threonine-rich region of RYBP.
RYBP probably stabilizes FANK1 by preventing polyubiquitinated FANK1 from proteasomal degradation.
RYBP induces tumor cell apoptosis through activating FANK-mediated AP-1 signaling pathway.