Prolonged administration of antidepressant drugs leads to increased binding of [3H]MPEP to mGlu5 receptors
详细信息 查看全文
- 作者：Gabriel Nowaka ; Lucyna Pomierny-Chamio艂ob ; Agata Siweka ; c ; Ewa Niedzielskab ; Bartosz Pomiernyb ; Agnieszka Pa艂ucha-Poniewieraa ; Andrzej Pilca ; nfpilc@cyf-kr.edu.pl" class="auth_mail ; pilc@if-pan.krakow.pl" class="auth_mail
- 关键词：[3H]MPEP ; mGlu5 receptors ; Homer proteins ; Escitalopram ; Reboxetine ; Milnacipran ; Moclobemide ; Imipramine ; MTEP
- 刊名：Neuropharmacology
- 出版年：September 2014
- 年：2014
- 卷：84
- 期：Complete
- 页码：46-51
- 全文大小：648 K
文摘
- •
Treatment with antidepressants or with mGlu5 antagonist MTEP was studied in rats.
- •
The mGlu5 receptor binding and/or mGlu5 protein level was evaluated brain structures.
- •
Increase in mGlu5 receptor Bmax and/or expression was found in cortex/hippocampus.
- •
The mGlu5 receptors may represent a target for antidepressant therapy.