Oral delivery of anticancer drugs II: the prodrug strategy

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• 作者：Silvia Mazzaferro ; Kawthar Bouchemal ; ^{Kawthar.bouchemal@u-psud.fr} ; Gilles Ponchel
• 刊名：Drug Discovery Today
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：18
• 期：1-2
• 页码：93-98
• 全文大小：214 K

文摘

Many anticancer drugs are sparingly water soluble and they show a low permeability at the intestinal level. Furthermore, their oral bioavailability is impaired because they are substrates of the cytochrome P450 and of the efflux pumps. The prodrug strategy, which is discussed in the present review, represents one of the different approaches to overcome these obstacles. In this review, we highlight the progresses of clinical development in the prodrug area for the oral administration of anticancer drugs.