Amyloid deposition detected with florbetapir F 18 (¹⁸F-AV-45) is related to lower episodic memory performance in clinically normal older individuals

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• 作者：Reisa A. Sperling^a ; ^{reisa@rics.bwh.harvard.edu} ; Keith A. Johnson^a ; ^b ; P. Murali Doraiswamy^c ; Eric M. Reiman^d ; Adam S. Fleisher^d ; ^e ; Marwan N. Sabbagh^f ; Carl H. Sadowsky^g ; Alan Carpenter^h ; Mat D. Davisⁱ ; Ming Lu^h ; Matthew Flitter^h ; Abhinay D. Joshi^h ; Christopher M. Clark^h ; Michael Grundman^j ; Mark A. Mintun^h ; Daniel M. Skovronsky^h ; Michael J. Pontecorvo^h ; AV45-A05 Study Group
• 关键词：Memory ; Amyloid ; Aging
• 刊名：Neurobiology of Aging
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：34
• 期：3
• 页码：822-831
• 全文大小：1133 K

文摘

The objective of this study was to evaluate the relationship of amyloid burden, as assessed by florbetapir F 18 (¹⁸F-AV-45) amyloid positron emission tomography, and cognition in healthy older control (HC) subjects. Seventy-eight HC subjects were assessed with a brief cognitive test battery and positron emission tomography (PET) imaging with ¹⁸F-AV-45. A standard uptake value ratio was computed for mean data from 6 cortical regions using a whole cerebellum reference region. Scans were also visually rated as amyloid positive or amyloid negative by 3 readers. Higher standard uptake value ratio correlated with lower immediate memory (r = ?0.33; p = 0.003) and delayed recall scores (r = ?0.25; p = 0.027). Performance on immediate recall was also lower in the visually rated amyloid positive compared with amyloid negative HC (p = 0.04), with a similar trend observed in delayed recall (p = 0.06). These findings support the hypothesis that higher amyloid burden is associated with lower memory performance among clinically normal older subjects. Longitudinal follow-up is ongoing to determine whether ¹⁸F-AV-45 may also predict subsequent cognitive decline.