Synthesis of novel hydrazone and azole functionalized pyrazolo[3,4-b]pyridine derivatives as promising anticancer agents

详细信息    查看全文

• 作者：P. Nagender^a ; R. Naresh Kumar^a ; G. Malla Reddy^a ; D. Krishna Swaroop^a ; Y. Poornachandra^b ; C. Ganesh Kumar^b ; B. Narsaiah^a ; ^{narsaiah@iict.res.in" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Pyrazolo[3 ; 4-b]pyridine ; Oxadiazole ; 1 ; 2 ; 4-Triazole ; Anticancer activity
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 September 2016
• 年：2016
• 卷：26
• 期：18
• 页码：4427-4432
• 全文大小：1530 K

文摘

A series of novel pyrazolo[3,4-b]pyridine based target compounds were synthesized starting from the key intermediate ethyl 2-(3-amino-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate 5 on reaction with hydrazine hydrate followed by reaction with different aldehydes, acid chlorides and isothiocyanates to form hydrazones 7, oxadiazoles 8, 1,2,4 triazoles 10 and thiadiazoles 11 respectively in high yield. All the final compounds were screened for anticancer activity against four human cancer cell lines. Among them, 1,2,4 triazole derivatives showed promising activity and compound 10d is identified as a lead molecule.