A preliminary evaluation of immune stimulation following exposure to metal particles and ions using the mouse popliteal lymph node assay
详细信息 查看全文
- 作者：Brooke E. Tvermoesa ; brooke.tvermoes@cardno.com" class="auth_mail" title="E-mail the corresponding author ; Kenneth M. Uniceb ; Bethany Winansc ; Michael Kovochichd ; Whitney V. Christianb ; 1 ; Ellen Donovanc ; Ernest S. Fungd ; Brent L. Finleyc ; Ian Kimbere ; Dennis J. Paustenbachc
- 关键词：Metals ; Particles ; Hypersensitivity ; Lymph node cell activation ; Immune stimulation ; Metal-on-metal implants ; Popliteal lymph node assay
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：308
- 期：Complete
- 页码：77-90
- 全文大小：1289 K
文摘
- •
Immune responses in mice were assessed following treatment with Cr2O3 particles with metal salts.
- •
The PLNA was negative (SI < 3) for all Cr2O3 particle doses.
- •
A LOAEL for immune activation was identified at 0.04 mg of metal particles with metal salts.
- •
A NOAEL for immune activation was identified at 0.01 mg of metal particles with metal salts.