Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism
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- 作者：Wenchun Fana ; b ; Dong Zhanga ; b ; Ping Qiana ; b ; Suhong Qiana ; b ; Mengge Wua ; b ; Huanchun Chena ; b ; Xiangmin Lia ; b ; lixiangmin@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Swine TRIM21 ; Foot-and-mouth disease virus ; Antiviral activity ; Antibodies ; Neutralization
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：32-40
- 全文大小：1472 K
文摘
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Swine TRIM21 (sTRIM21) is induced by type I interferon in porcine kidney cells.
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15">sTRIM21 did not affect foot-and-mouth disease virus (FMDV) infection in BHK-21 cells.
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sTRIM21 restricts FMDV infection in the presence of FMDV specific antibodies.
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sTRIM21 mediates degradation of FMDV through proteasome dependent manner.