Melatonin modulates drug-induced acute porphyria

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• 作者：Sandra M. Lelli ; Marta B. Mazzetti¹ ; Leonor C. San Mart&iacute ; n de Viale ; ¹ ; ^{dimxsa@qb.fcen.uba.ar}
• 关键词：Melatonin (PubChem CID ; 896) ; Allylisopropylacetamide (PubChem CID ; 9297) ; 3 ; 5-Diethoxycarbonyl-1 ; 4-dihydro-2 ; 4 ; 6-collidine (PubChem CID ; 12446) ; Heme (PubChem CID ; 26945) ; 5-Aminolevulinic acid (PubChem CID ; 137) ; Porphobilinogen (PubChem CID ; 1021)
• 刊名：Toxicology Reports
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：3
• 期：Complete
• 页码：141-147
• 全文大小：585 K
• 卷排序：3

文摘

Melatonin partially eliminates the AIA/DDC-induced decrease in the activity of the gluconeogenic enzymes PEPCK and G6Pase. Melatonin favors a glucose-mediated down-regulating effect on AIA/DDC-induced ALA-S. Melatonin reduces AIA/DDC-increases in lipid peroxidation. Melatonin partially reverts the AIA/DDC-induced increase in ALA and PBG levels. The results obtained suggest the hypothetical use of Mel as co-treatment for acute porphyria.