G4 DNA in ras genes and its potential in cancer therapy
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- 作者：Susanna Cogoi ; susanna.cogoi@uniud.it" class="auth_mail" title="E-mail the corresponding author ; Luigi E. Xodo ; luigi.xodo@uniud.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：KRAS ; HRAS ; NRAS ; G-quadruplex ; Antigene strategies ; Promoter ; 5&prime ; -UTR
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1859
- 期：4
- 页码：663-674
- 全文大小：1249 K
文摘
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Transcription of KRAS and HRAS is regulated by a G4/i-motif switch.
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Nuclear proteins with DNA unfolding activity recognize the G4/i-motif switch.
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Antrathiophenediones binding to G4-DNA promoter strongly inhibit HRAS expression.
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Photoactivated cationic porphyrins binding to 5′-UTR G4-RNAs suppress KRAS.
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G4-oligonucleotides suppress ras expression through a decoy mechanism.