Pharmacological activation of aldehyde dehydrogenase 2 promotes osteoblast differentiation via bone morphogenetic protein-2 and induces bone anabolic effect

详细信息    查看全文

• 作者：Monika Mittal^a ; ¹ ; Subhashis Pal^a ; Shyamsundar Pal China^a ; ¹ ; Konica Porwal^a ; Kapil Dev^b ; ¹ ; Richa Shrivastava^c ; Kanumuri Siva Rama Raju^d ; Mamunur Rashid^d ; Arun Kumar Trivedi^e ; Sabyasachi Sanyal^e ; Muhammad Wahajuddin^d ; Smrati Bhaduria^c ; Rakesh Maurya^b ; Naibedya Chattopadhyay^a ; ¹ ; ^{n_chattopadhyay@cdri.res.in}
• 关键词：Alda-1 ; Osteoanabolic ; Bone regeneration ; Peak bone mass ; Pharmacokinetics ; Post-menopausal osteoporosis
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：316
• 期：Complete
• 页码：63-73
• 全文大小：1286 K
• 卷排序：316

文摘

Alda-1 induced osteoblast differentiation that involved upregulation of ALDH2 and BMP-2 Alda-1 attenuated acetaldehyde-induced inhibition of osteoblast differentiation Alda-1 enhanced bone regeneration at the fracture site and peak bone mass achievement Alda-1 reversed trabecular osteopenia in OVX rats via an osteoanabolic mechanism