- 作者：Edda Bahlmann ; Carsten Schneider ; Korff Krause ; Klaus Hertting ; Sigrid Boczor ; Thomas Wollner ; Jens-Uwe Voigt ; Karl-Heinz Kuck
- 关键词：Tako-Tsubo cardiomyopathy ; Apical ballooning ; Echocardiography
- 刊名：International Journal of Cardiology
- 出版年：2008
- 出版时间：20 February 2008
- 年：2008
- 卷：124
- 期：1
- 页码：32-39
- 全文大小：520 K
Methods
Fifteen patients with TTC and transthoracic echocardiography (TTE) at their admission, were reviewed (2001 to 2006). Follow-up (F/U) TTE was performed in varying intervals. To compare diameters of posterior wall (PW), interventricular septum (IVS), left atrium (LA), LV in end-diastole (LVED) and LV in end-systole (LVES) and valve insufficiencies, patients with comparable F/U are selected.
Results
Fourteen patients were female (mean age 69.6 years). Angiography demonstrated LV systolic dysfunction with mean ejection fraction (EF) of 31.3 % . In the acute-phase (day 0 to day 3), TTE showed a mean EF of 35.7 % , not significantly different from EF obtained in angiography. Short-term F/U was performed in 9 patients after median time-interval of 20 days with an increase to a mean EF of 58.8 % . F/U in 2006 has been performed in 10 patients (median time-interval 18.7 months) and showed normal EF. No significant difference in diameters of LA, LVED and LVES could be obtained comparing baseline and long-term data (p = 0.493, p = 0.790 and p = 0.275). PW and IVS were significantly thicker at baseline compared to TTE {greater than or equal to} day 62 of F/U (p = 0.003 and p = 0.026). At baseline mitral valve insufficiency (MI) was mild in 50.0 % and moderate in 12.5 % , mild and moderate tricuspid valve insufficiency (TI) was recognized in 50 % (25 % respectively). MI and TI were regredient in F/U. In three patients an intraventricular systolic flow acceleration could be detected in the acute phase.
Conclusions
Characteristics of TTC, besides transient LV apical ballooning are also a significant change in LV wall thickness and reversible valve insufficiencies.