Link between leptin and interleukin-6 levels in the initial phase of obesity related inflammation

详细信息    查看全文

• 作者：Ingeborg Stelzer^a ; Sieglinde Zelzer^a ; Reinhard B. Raggam^a ; Florian Prü ; ller^a ; Martie Truschnig-Wilders^a ; Andreas Meinitzer^a ; Wolfgang J. Schnedl^b ; Renate Horejsi^c ; Reinhard Mö ; ller^c ; Daniel Weghuber^d ; Gloria Reeves^e ; Teodor T. Postolache^f ; Harald Mangge^a ; ^{harald.mangge@klinikum-graz.at}
• 关键词：ALT/GPT ; alanin-aminotransferase ; BMI ; body mass index ; CRP ; C-reactive protein ; CT ; computed tomography ; ELISA ; enzyme-linked immunosorbent assay ; HDL ; high-density lipoprotein ; HOMA-IR ; homeostatic model assessment&ndash ; insulin resistance ; IL-6 ; interl
• 刊名：Translational Research
• 出版年：2012
• 出版时间：February 2012
• 年：2012
• 卷：159
• 期：2
• 页码：118-124
• 全文大小：203 K

文摘

The mechanisms underlying the pathogenesis of obesity-related atherosclerosis remain to be clarified. To investigate the preclinical phase, interleukin-6 (IL-6) plasma levels were analyzed together with clinical, anthropometric, inflammatory, and metabolic variables in a well-defined cohort of 677 young and middle-aged overweight/obese and normal-weight subjects. In the juvenile and adult overweight/obese study group, IL-6 levels were increased significantly compared with normal-weight, age-matched controls (P < 0.001). In both juveniles and adults, higher levels of IL-6 were observed in obese compared with overweight participants. Subjects with metabolic syndrome (MS) had significantly higher IL-6 levels than those without MS. In juveniles, leptin, and in adults, the waist-to-height ratio, turned out to be the best predictor of IL-6 plasma levels in a multiple stepwise regression model. Taken together, in every age group, interleukin-6 is associated positively with the grade of overweight. Interestingly, leptin, which is the best known adipokine, is associated predictively with interleukin-6 plasma levels only in juveniles, which may indicate an important role of this molecule in the initiation of obesity-related inflammation.