RhBMP-2-induced radiculitis in patients undergoing transforaminal lumbar interbody fusion: relationship to dose

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• 作者：Alan T. Villavicencio ; MD^a ; ^b ; Sigita Burneikiene ; MD^a ; ^b ; ^{sigitab@bnasurg.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Complications ; Incidence ; Radiculitis ; Recombinant human bone morphogenetic protein-2 ; RhBMP-2 ; Transforaminal lumbar interbody fusion
• 刊名：The Spine Journal
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：16
• 期：10
• 页码：1208-1213
• 全文大小：336 K

文摘

Recombinant human bone morphogenetic protein-2 (rhBMP-2) remains the primary synthetic osteoinductive material used in spinal fusion surgery today. The early inflammation reaction to rhBMP-2 manifesting with radicular symptoms has been previously reported in patients undergoing transforaminal lumbar interbody fusion (TLIF). There is a disagreement with regard to the factors affecting its occurrence and whether such symptoms are dose dependent.

Purpose

The purpose of this analysis was to determine the incidence of rhBMP-2-induced radiculitis and its relationship to dose.

Study Design/Setting

A retrospective cohort analysis was performed of the prospectively collected data.

Patient Sample

All consecutive patients (n=204) who underwent one- or two-level TLIF and instrumented posterolateral fusion with an off-label rhBMP-2 use were included in this analysis.

Outcome Measures

The patients who developed new radicular symptoms after initial improvement postoperatively and had sterile fluid collections indicative of inflammatory process, or in the absence of any structural abnormalities that would explain these symptoms on imaging studies, were deemed to have rhBMP-2-induced radiculitis.

Methods

Magnetic resonance imaging (MRI) scans were obtained for all patients who developed postoperative radicular symptoms. Correlations between the total rhBMP-2 dose, dose per spinal level, and incidence of radiculitis were evaluated while controlling for age, sex, number of TLIF levels, and surgeon.

Results

The incidence of postoperative radiculitis was 11.3% (23 out of 204). The average total rhBMP-2 dose was 4.9 mg (range=2.1–12) and the average dose per spinal level was 3.8 mg (range=1.05–12). Logistic regression analysis did not identify any significant correlations between the rhBMP-2 doses and the incidence of radiculitis (p=.6).

Conclusion

The incidence of rhBMP-2-induced radiculitis in patients undergoing TLIF is quite high, but there were no dose-related correlations found. The study, however, cannot rule out a possibility that a larger variation in bone morphogenetic protein (BMP) doses could still be a factor in the development of rhBMP-2-associated radiculitis.