- 作者：A. Sancho ; A. Á ; vila ; E. Gavela ; S. Beltrá ; n ; J.E. Ferná ; ndez-Ná ; jera ; P. Molina ; J.F. Crespo ; L.M. Pallardó
- 关键词：Blood transfusion ; Evaluation of the professional practices ; Continuous medical training
- 刊名：Transplantation Proceedings
- 出版年：2007
- 出版时间：September 2007
- 年：2007
- 卷：39
- 期：7
- 页码：2202-2204
- 全文大小：57 K
Patients and methods
We analyzed a series of 337 patients with renal allografts having a mean follow-up of 53.4 ± 30.6 months. We excluded 39 patients obese at transplantation. We compared the evolution of 134 OW patients (45.5 % ), and 160 patients (54.4 % ) with a body mass index <25 (NW group).
Results
OW patients were older (P = .000) with a higher prevalence of hypertension (P = .028), left ventricular hypertrophy (P = .014), and dyslipidemia (P = .001). They had received kidneys from older donors (P = .019). OW patients showed a higher incidence of acute tubular necrosis (ATN) (P = .006), without a higher incidence of acute rejection episodes (P = .756). Postransplant diabetes mellitus was more frequent (P = .000), and systolic blood pressure (P < .05), total cholesterol (P < .05), and tryglicerides were higher (P < .05) in the OW group. Serum creatinine at 6 months (P = .007) and proteinuria >0.5 g/24 hours, (P = .023) were higher among the OW group. Graft survival was not different between groups, but patient survival was lower in the OW group (P = .002). A logistic regression analysis showed that the recipient age (RR: 5.243) and the presence of OW (RR: 1.100) were independent prognostic factors for patient death.
Conclusions
OW was a common situation among renal transplant candidates. It was associated with worse cardiovascular and metabolic profiles. OW patients showed worse allograft function and lower patient survival. A major effort must be exerted to avoid excessive weight gain, particularly among those OW at transplantation.