Minocycline enhances inhibitory transmission to substantia gelatinosa neurons of the rat spinal dorsal horn
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- 作者：H.-Z. Pengb ; &dagger ; ; L.-X. Mab ; &dagger ; ; M.-H. Lvc ; T. Hub ; T. Liua ; c ; liutaomm@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DRG ; dorsal root ganglion ; EPSCs ; excitatory postsynaptic currents ; HVA ; high voltage-activated ; IPSCs ; inhibitory postsynaptic currents ; LVA ; low voltage-activated ; mIPSCs ; miniature IPSCs ; sEPSCs ; spontaneous EPSCs ; SG ; substantia gelatinosa ; sIPSCs ; spontaneous IPSCs ; TEA ; tetraethylammonium ; TTX ; tetrodotoxin ; VH ; holding potential
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：319
- 期：Complete
- 页码：183-193
- 全文大小：2332 K
文摘
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Minocycline increases inhibitory synaptic transmission in SG neurons.
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Minocycline can enhance both glycinergic and GABAergic sIPSC frequencies.
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The facilitation induced by minocycline is independent of neuronal activity.
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Enhancement of minocycline on IPSCs is ascribed to presynaptic calcium influx.