CR+ spinal dorsal horn neurons form excitatory (Typical) and inhibitory (Atypical) subpopulations.
Typical neurons received mixed (GABAergic and glycinergic) inhibition.
Atypical neurons received inhibition dominated by glycine.
Noradrenaline and serotonin evoke responses in Typical but not Atypical neurons.
Enkephalins evoke responses in Atypical but not typical neurons.