Opioid subtype- and cell-type-dependent regulation of inhibitory synaptic transmission in the rat insular cortex
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- 作者：Eiko Yokotaa ; Yuko Koyanagia ; b ; koyanagi.yuuko@nihon-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kiyofumi Yamamotoc ; d ; Yoshiyuki Oia ; b ; Noriaki Koshikawac ; d ; Masayuki Kobayashic ; d ; e ; kobayashi.masayuki@nihon-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACC ; anterior cingulate ; ACSF ; artificial cerebrospinal fluid ; AI ; agranular region ; DAMGO ; [D-Ala2 ; N-Me-Phe4 ; Gly5-ol]-Enkephalin acetate salt ; DPDPE ; [D-Pen2 ; 5]-Enkephalin hydrate ; FS ; fast-spiking ; IC ; insular cortex ; Pyr ; pyramidal ; uIPSCs ; unitary inhibitory postsynaptic currents
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：17 December 2016
- 年：2016
- 卷：339
- 期：Complete
- 页码：478-490
- 全文大小：2814 K
文摘
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We tested the hypothesis that opioid receptor subtypes differentially regulate IPSCs in the insular cortex.
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A mu opioid receptor agonist suppressed unitary IPSCs to fast-spiking GABAergic neurons, but not to pyramidal neurons.
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A delta opioid receptor agonist suppressed unitary IPSCs from fast-spiking to both fast-spiking and pyramidal neurons.
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A kappa opioid receptor agonist had little effect on unitary IPSCs.
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These specific synaptic regulations among opioid receptor agonists may result in their differential analgesic effects.