α4β2^∗ nicotinic receptors stimulate GABA release onto fast-spiking cells in layer V of mouse prefrontal (Fr2) cortex

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• 作者：Patrizia Aracri^a ; ^&dagger ; ; Simone Meneghini^a ; ^&dagger ; ; Aurora Coatti^a ; Alida Amadeo^b ; Andrea Becchetti^a ; ^{andrea.becchetti@unimib.it}
• 关键词：5-IA ; 5-iodo-3-[2(S)-azetidinylmethoxy]pyridine ; ACh ; acetylcholine ; ADNFLE ; autosomal dominant nocturnal frontal lobe epilepsy ; AHP ; after-hyperpolarization ; AP ; action potential ; AP5 ; d(&minus ; )-2-amino-5-phosphono-pentanoic acid ; BSA ; bovine serum albumin ; CNQX ; 6-cyano-7-nitroquinoxaline-2 ; 3-dione ; DF ; degrees of freedom ; DHβE ; dihydro-β-erythroidine ; Fr2 ; frontal area 2 ; FS ; fast-spiking ; IPSC ; inhibitory postsynaptic current ; KS ; Kolmogorov&ndash ; Smirnov ; mIPSC ; miniature IPSC ; MLA ; methyl
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：48-61
• 全文大小：3393 K
• 卷排序：340

文摘

α4β2∗ nAChRs stimulate IPSCs in FS interneurons, in layer V of the mouse PFC (Fr2). In P16–P63 mice, nicotine increased both IPSC and mIPSC frequencies. GABAergic terminals adjacent to PV+ cells expressed α4 nAChR. The percentage of FS cells with somatic α4β2∗ currents decreased with age. Hence, nAChRs may be able to induce local circuit disinhibition in Fr2 PFC.