Glycine blocks long-term potentiation of GABAergic synapses in the ventral tegmental area
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- 作者：Y.-Z. Guana ; b ; md-guan@163.com" class="auth_mail" title="E-mail the corresponding author ; J.-H. Yea ; ye@njms.rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：aCSF ; artificial cerebrospinal fluid ; DNQX ; 6 ; 7-dinitroquinoxaline-2 ; 3-dione ; eIPSC ; evoked inhibitory postsynaptic current ; GABA ; gamma-aminobutyric acid ; GABAAR ; GABAA receptor ; GlyR ; glycine receptor ; GLYTs ; glycine transporters ; HFS ; high-frequency stimulation ; IPSC ; inhibitory postsynaptic current ; LTPGABA ; long-term potentiation of GABA-mediated synapses ; NMDA ; N-methyl-d-aspartate ; NO ; nitric oxide ; PPR ; paired pulse ratio ; sEPSC ; spontaneous excitatory postsynaptic current ; SNAP ; S-nitro
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：24 March 2016
- 年：2016
- 卷：318
- 期：Complete
- 页码：134-142
- 全文大小：1580 K
文摘
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A transit exposure to 10 μM glycine prevents trains of HFS from producing LTPGABA.
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Glycine does not prevent potentiation of IPSCs induced by the NO donor SNAP.
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Glycine does not prevent potentiation of evoked IPSCs induced by NMDA and glycine.
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Glycine lowers the frequency of spontaneous EPSCs in the putative dopamine neurons.
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Glycine inhibits EPSCs by activating strychnine-sensitive glycine receptors.