Effects of chlorogenic acid on voltage-gated potassium channels of trigeminal ganglion neurons in an inflammatory environment
详细信息 查看全文
- 作者：Fei Liua ; Xiao-Wen Lub ; Yu-Jiao Zhanga ; Liang Koub ; Ning Songa ; Min-Ke Wua ; Min Wanga ; Hang Wanga ; Jie-Fei Shen ; DDS & PhDa ; shenjiefei@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; jiefei.shen@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Trigeminal ganglion neurons ; Chlorogenic acid ; Prostaglandin E2 ; Patch clamp ; Voltage-gated potassium channels
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：119-125
- 全文大小：1429 K
文摘
- •
K+ channels are potential therapeutic targets for trigeminal inflammatory pain.
- •
CGA antagonized the effects of PGE2 on the subtypes of K+ channels on TGNs.
- •
Mechanisms of CGA analgesia derived from its different behaviors on IK,Aand IK,V.