Comparison of cocaine reinforcement in lean and obese Zucker rats: Relative potency and reinstatement of extinguished operant responding

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• 作者：E. Andrew Townsend^a ; ^b ; ^{s52drew@gmail.com} ; Kevin B. Freeman^b
• 关键词：Obesity ; Zucker rat ; Cocaine ; Self-administration
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：170
• 期：Complete
• 页码：88-92
• 全文大小：414 K
• 卷排序：170

文摘

Although previous studies have reported increases in measures of food reinforcement in Zucker rats, it appears that cocaine reinforcement is unaltered in this strain. Acquisition of stable cocaine self-administration was similar between lean and obese Zucker rats. The reinforcing potency of cocaine is similar between lean and obese Zucker rats. The reinstating effects of a cocaine-associated light stimulus and cocaine itself are similar in lean and obese Zucker rats.