Spike-timing-dependent plasticity in the human dorso-lateral prefrontal cortex

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• 作者：Elias Paolo Casula^a ; Maria Concetta Pellicciari^a ; Silvia Picazio^a ; Carlo Caltagirone^a ; ^b ; Giacomo Koch^a ; ^c ; ^{g.koch@hsantalucia.it}
• 关键词：TMS ; transcranial magnetic stimulation ; EEG ; electroencephalography ; STDP ; spike-timing-dependent plasticity ; GABA ; gamma-aminobutyric acid ; MEP ; motor-evoked potential ; TEP ; TMS-evoked potential ; DLPFC ; dorso-lateral prefrontal cortex ; M1 ; primary motor cortex ; PPC ; posterior parietal cortex ; PAS ; paired associative stimulation ; ERP ; event-related responses ; ICA ; independent component analysis ; RMT ; resting motor threshold ; AMT ; active motor threshold ; FDI ; first dorsal interosseous ; TOI ; time
• 刊名：NeuroImage
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：143
• 期：Complete
• 页码：204-213
• 全文大小：3962 K
• 卷排序：143

文摘

We studied spike timing-dependent plasticity (STDP) over fronto-parietal network. We repetitively applied fronto-parietal (FP) and parieto-frontal (PF) bi-focal TMS. DLPFC TMS-evoked activity is oppositely modulated by FP and PF stimulation. TMS-evoked activity modulations are paralleled by beta/gamma oscillations changes. We provide the first direct demonstration of STDP over DLPFC.