Functional aspects of early brain development are preserved in tuberous sclerosis complex (TSC) epileptogenic lesions
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- 作者：Gabriele Ruffoloa ; 1 ; Anand Iyerb ; 1 ; Pierangelo Cifellia ; e ; Cristina Rosetid ; Angelika Mü ; hlebnerb ; f ; Jackelien van Scheppingenb ; Theresa Schollf ; Johannes A. Hainfellnerg ; Martha Feuchtf ; Pavel Krsekh ; Josef Zamecniki ; Floor E. Jansenj ; Wim G.M. Splietk ; Cristina Limatolaa ; l ; Eleonora Aronicab ; c ; e.aronica@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author ; Eleonora Palmaa ; d ; eleonora.palma@uniroma1.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid ; AMPAR ; AMPA receptor ; CCCs ; cation chloride cotransporters ; FCD ; focal cortical dysplasia ; GABA ; gamma-aminobutyric acid ; GABAAR ; GABA type A receptor ; EGABA ; GABAA reversal potential ; TSC ; tuberous sclerosis complex
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：93-101
- 全文大小：695 K
文摘
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EGABA shifts during normal brain development in human cortical samples.
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GLUA1/GLUA2 mRNA expression parallels the normal development process.
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EGABA and the GLUA1/GLUA2 mRNA expression do not change in TSC tissues during development.
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This lack of EGABA shift is due to an altered NKCC1/KCC2 mRNA expression in TSC.