In Situ Potentiostatic Deposition of Calcium Phosphate with Gentamicin-Loaded Chitosan Nanoparticles on Titanium Alloy Surfaces

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• 作者：Midhun B. Thomas^a ; ¹ ; Noah Metoki^a ; ¹ ; Daniel Mandler^b ; ^{daniel.mandler@mail.huji.ac.il} ; Noam Eliaz^a ; ^{neliaz@tau.ac.il}
• 关键词：FDA ; U.S. Food and Drug Administration ; CaP ; calcium phosphate ; HAp ; hydroxyapatite ; ED ; electrodeposition ; DCPD ; dibasic calcium phosphate dehydrate (Brushite) ; OCP ; octacalcium phosphate ; NPs ; nanoparticles ; TPP ; pentasodium tripolyphosphate hexahydrate ; PBS ; phosphate buffered saline ; DI ; dionized ; SCE ; saturated calomel electrode ; ESEM ; environmental scanning electron microscope ; XRD ; X-ray diffraction ; TCP ; tricalcium phosphate
• 刊名：Electrochimica Acta
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：222
• 期：Complete
• 页码：355-360
• 全文大小：1054 K
• 卷排序：222

文摘

Bone implants must be biocompatible and are usually built to promote osseointegration, e.g. by application of plasma spray calcium phosphate (CaP) coating. The risk of infection and biofilm formation on implant surfaces is a well-known problem. The combination of electrochemically deposited CaP coating with antibiotics may offer significant benefits. Here, we demonstrate an innovative in situ electrodeposition of gentamicin encapsulated in chitosan nanoparticles along with CaP. The deposition of the coating was observed and studied at several temperatures. A high drug loading into the coating and a controlled release of the drug over two days were demonstrated.