Analogues of cytotoxic squamocin using reliable reactions: new insights into the reactivity and role of the α,β-unsaturated lactone of the annonaceous acetogenins
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- 作者：Romain A. Duval ; Erwan Poupon ; Vanessa Romero ; Eva Peris ; Guy Lewin ; Diego Cortes ; Ulrich Brandt and Reynald Hocquemiller
- 关键词：Annonaceous acetogenins ; Squamocin ; Unsaturated lactone ; Chemistry in water ; Diels– ; Alder ; Click chemistry
- 刊名：Tetrahedron
- 出版年：2006
- 出版时间：26 June 2006
- 年：2006
- 卷：62
- 期：26
- 页码：6248-6257
- 全文大小：363 K
文摘
A small library of squamocin analogues has been prepared and screened biologically (cytotoxicity, inhibition of mitochondrial complex I and complex III). To centre diversity on a crucial part of the molecule (i.e., the α,β-unsaturated lactone), an original and reliable lactone opening reaction has been discovered and exploited among other efficient reactions.