Effects of nicotinic receptor agonists on bladder afferent nerve activity in an in vitro bladder-pelvic nerve preparation
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- 作者：Yongbei Yu ; yyu407@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Stephanie L. Daugherty ; William C. de Groat
- 关键词：ACh ; acetylcholine ; AMN ; atropine methyl nitrate ; AP ; action potential ; EPI ; epibatidine ; BAN ; bladder afferent nerve ; MEC ; mecamylamine ; NNR ; neuronal nicotinic receptors ; NO ; nitric oxide ; NOS ; nitric oxide synthase ; PPADS ; pyridoxal-phosphate-6-azophenyl-2&prime ; 4&prime ; -disulfonate
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：1637
- 期：Complete
- 页码：91-101
- 全文大小：1821 K
文摘
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Nicotinic agonists modulate firing of mechano-sensitive bladder afferent nerves (BAN).
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Agonists applied to the bladder lumen enhance mechano-sensitive BAN firing.
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Agonists applied to the bladder serosal surface suppress mechano-sensitive BAN firing.
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Agonists applied to the bladder serosal surface also elicit BAN firing.
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Mecamylamine, a nicotinic antagonist blocks the effects of agonists.