Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy
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- 作者：Robert J. Heuermanna ; 1 ; r-heuermann@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Thomas C. Jaramilloa ; 1 ; 2 ; tom.jaramillo@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Shui-Wang Yingc ; yingsw200@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Benjamin A. Suterb ; ben.suter@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kyle A. Lymana ; kyle-lyman@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Ye Hana ; ye-han@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Alan S. Lewisa ; 3 ; alan.lewis@yale.edu" class="auth_mail" title="E-mail the corresponding author ; Thomas G. Hamptond ; hampton@mousespecifics.com" class="auth_mail" title="E-mail the corresponding author ; Gordon M.G. Shepherdb ; g-shepherd@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Peter A. Goldsteinc ; pag2014@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Dane M. Chetkovicha ; b ; d-chetkovich@northwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCN ; hyperpolarization-activated cyclic-nucleotide-gated ; RTN ; reticular thalamic nucleus ; SWD ; spike&ndash ; wave discharge ; TC ; thalamocortical ; TRIP8b ; tetratricopeptide-containing Rab8b-interacting protein
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：81-92
- 全文大小：1524 K
文摘
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TRIP8b is an auxiliary subunit of HCN channels that regulates neuronal excitability.
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We noted spontaneous absence seizures during EEG recordings of TRIP8b knockout mice.
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We found reduced HCN channel function (Ih) in neurons of the cortex and thalamus.
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Normal Ih in the reticular thalamic nucleus may limit seizure severity in these mice.