Stress induces equivalent remodeling of hippocampal spine synapses in a simulated postpartum environment and in a female rat model of major depression

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• 作者：Judith Baka^a ; Eszter Csakvari^a ; Orsolya Huzian^a ; Nikoletta Dobos^a ; Laszlo Siklos^a ; Csaba Leranth^b ; ^c ; Neil J. MacLusky^d ; Ronald S. Duman^c ; ^e ; Tibor Hajszan^a ; ^b ; ^{hajszan.tibor@brc.mta.hu}
• 关键词：EIA ; enzyme immunoassay ; PPD ; postpartum depression
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：343
• 期：Complete
• 页码：384-397
• 全文大小：1045 K
• 卷排序：343

文摘

Postpartum stress causes a loss of hippocampal spine synapses. Pregnancy levels of ovarian hormones prevent the synaptolytic effect of stress. This preventive effect of ovarian hormones is mediated by reduced stress responsiveness. These data provide further support for the “synaptogenic hypothesis” of depression.