MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium
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- 作者：Baojun Zhang1 ; 4 ; Si-Qi Liu1 ; 4 ; Chaoran Li1 ; Erik Lykken1 ; Shan Jiang1 ; Elizabeth Wong1 ; Zhihua Gong2 ; Zhongfen Tao3 ; Bo Zhu2 ; Ying Wan3 ; Qi-Jing Li1 ; qi-jing.li@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：44
- 期：3
- 页码：568-581
- 全文大小：5677 K
文摘
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miR-23a controls expression of PPIF and the mitochondria permeability transition
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miR-23a is essential for ROS equilibrium in antigen-stimulated CD4+ T cells
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Loss of miR-23a in CD4+ T cells leads to rapid activation-induced necrosis
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During acute infection, miR-23a in T cells is vital for systemic immune homeostasis