NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer
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- 作者：Iok In Christine Chio1 ; 2 ; Seyed Mehdi Jafarnejad3 ; Mariano Ponz-Sarvise1 ; 2 ; 10 ; Youngkyu Park1 ; 2 ; Keith Rivera1 ; Wilhelm Palm4 ; John Wilson1 ; Vineet Sangar5 ; Yuan Hao1 ; Daniel Ö ; hlund1 ; 2 ; Kevin Wright1 ; 2 ; Dea Filippini1 ; 2 ; Eun Jung Lee1 ; 2 ; Brandon Da Silva1 ; 2 ; Christina Schoepfer1 ; 2 ; John Erby Wilkinson6 ; Jonathan M. Buscaglia7 ; Gina M. DeNicola8 ; Herve Tiriac1 ; 2 ; Molly Hammell1 ; Howard C. Crawford6 ; Edward E. Schmidt9 ; Craig B. Thompson4 ; Darryl J. Pappin1 ; Nahum Sonenberg3 ; David A. Tuveson1 ; 2 ; dtuveson@cshl.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：11 August 2016
- 年：2016
- 卷：166
- 期：4
- 页码：963-976
- 全文大小：3696 K
文摘
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Nrf2 supports pancreatic tumor maintenance
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Nrf2 inhibits oxidation of specific translational regulatory factors
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Nrf2 promotes EGFR signaling to fuel cap-dependent mRNA translation
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Combined targeting of AKT and glutathione synthesis inhibits pancreatic cancer