Upregulation of miR-556-5p promoted prostate cancer cell proliferation by suppressing PPP2R2A expression

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• 作者：Wei Zhao^a ; ^b ; Longbin Cao^b ; Sha Zeng^c ; Haiping Qin^c ; Tongyi Men^a ; ^{tongyimen@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：miR-556-5p ; Prostate cancer ; PPP2R2A ; Cell proliferation
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：75
• 期：Complete
• 页码：142-147
• 全文大小：1332 K

文摘

The prognosis and survival rate of prostate cancer are very poor. Previous studies have shown that miR-556-5p have emerged as important regulators in cancer cell biological processes. The role of miR-556-5p in prostate cancer remains unclear. In this study, expression of miR-556-5p in prostate cancer cell lines and tissues was upregulated. Result of MTT assays, colony formation and anchorage-independent growth assays demonstrated that overexpression of miR-556-5p promoted prostate cancer cell growth. Additionally, PPP2R2A was identified as a direct target of miR-556-5p. Ectopic expression of miR-556-5p led to downregulation of PPP2R2A protein, which resulted in the downregulation of p27, upregulation of cyclin D1. Taken together, our data provide compelling evidence that miR-556-5p functions as an onco-miRNA and participates in prostate cancer carcinogenesis by suppressing PPP2R2A expression.