Immunosuppressive drugs impairs antibody response of the polysaccharide and conjugated pneumococcal vaccines in patients with Crohn's disease
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- 作者：Bjø ; rn Kantsø ; a ; bjk@ssi.dk" class="auth_mail" title="E-mail the corresponding author ; Sofie Ingdam Halkjæ ; rb ; Ole Ø ; stergaard Thomsenc ; Erika Belardc ; Ida Benedikte Gottschalckc ; Charlotte Svæ ; rke Jø ; rgensena ; Karen A. Krogfeltd ; Hans-Christian Slotvedd ; Helene Ingelsd ; Andreas Munk Petersenb ; e
- 关键词：13-Valent conjugated pneumococcal vaccine ; 23-Valent pneumococcal polysaccharide vaccine ; Crohn's disease ; Inflammatory bowel disease ; Pneumococcus ; Vaccination
- 刊名：Vaccine
- 出版年：2015
- 出版时间：5 October 2015
- 年：2015
- 卷：33
- 期：41
- 页码：5464-5469
- 全文大小：665 K
文摘
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PCV13 and PPV23 were studied in Crohn's disease patients.
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PCV13 induces higher serotype specific antibody response in Crohn's disease patients than PPV23.
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Immunosuppressive drugs impaired the antibody response to PCV13 and PPV23.
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TNF-伪 antagonist further impaired the response to PCV13 and PPV23.