Oxidative stress intensity-related effects of cadmium (Cd) and paraquat (PQ) on UV-damaged-DNA binding and excision repair activities in zebrafish (Danio rerio) embryos
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- 作者：Li-Bin Ling ; Yung Chang ; Chia-Wei Liu ; Po-Ling Lai ; Todd Hsu ; toddhsu@mail.ntou.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cadmium ; Nucleotide excision repair ; Oxidative stress ; Paraquat ; UV ; Zebrafish
- 刊名：Chemosphere
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：167
- 期：Complete
- 页码：10-18
- 全文大小：1649 K
文摘
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UV-DDB 2 gene expression was activated in Cd and PQ-exposed zebrafish embryos.
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Cd and PQ triggering weak oxidative stress stimulated UV-damaged-DNA excision repair.
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PQ triggering strong oxidative stress inhibited UV- and cisplatin-damaged-DNA repair.
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Up- or down-regulation of excision repair correlated with 6-4PP binding activity.