Proteomic analysis of the Rett syndrome experimental model mecp2^Q63X mutant zebrafish

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• 作者：Alessio Cortelazzo^a ; ^b ; ^c ; ¹ ; ^{alessio.cortelazzo@biologo.onb.it} ; Thomas Pietri^d ; ¹ ; Claudio De Felice^e ; ¹ ; Silvia Leoncini^a ; ^f ; Roberto Guerranti^b ; ^c ; Cinzia Signorini^f ; Anna Maria Timperio^g ; Lello Zolla^g ; Lucia Ciccoli^f ; Joussef Hayek^a
• 关键词：Energy metabolism ; Muscle ; Oxidative stress ; Rett syndrome ; Zebrafish
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：154
• 期：Complete
• 页码：128-133
• 全文大小：593 K
• 卷排序：154

文摘

Effects of mecp2 mutation on whole protein expression in zebrafish LC–ESI–MS/MS identified 20 differentially expressed proteins vs. wild-type. Identified proteins imply energy depletion, redox imbalance and muscle deficit. The majority of protein changes occur already at larval stage. Protein expression changes indicate the broad impact of mecp2 mutations.